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Multiple Choice

Which statement about melioidosis treatment is NOT true?

Melioidosis treatment relies on two phases: an IV intensive phase to control the acute infection, followed by a prolonged oral eradication (maintenance) phase to prevent relapse. The length of the oral phase is not a fixed short period; it is tailored to the infection site and clinical response, with durations typically spanning several months. The statement claiming oral maintenance therapy lasts no more than 30 days after IV therapy is not true because eradication therapy usually runs for about 3–6 months, and longer for deep-seated infections. This extended course is essential to fully eradicate Burkholderia pseudomallei and minimize relapse. Initial IV therapy is indeed critical for severe disease, and oral maintenance therapy after IV treatment is part of the standard approach, with duration adjusted based on response and infection site.

Melioidosis treatment relies on two phases: an IV intensive phase to control the acute infection, followed by a prolonged oral eradication (maintenance) phase to prevent relapse. The length of the oral phase is not a fixed short period; it is tailored to the infection site and clinical response, with durations typically spanning several months.

The statement claiming oral maintenance therapy lasts no more than 30 days after IV therapy is not true because eradication therapy usually runs for about 3–6 months, and longer for deep-seated infections. This extended course is essential to fully eradicate Burkholderia pseudomallei and minimize relapse. Initial IV therapy is indeed critical for severe disease, and oral maintenance therapy after IV treatment is part of the standard approach, with duration adjusted based on response and infection site.