Glanders is a disease caused by Burkholderia mallei and primarily affects which animal?

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Glanders is caused by Burkholderia mallei and is primarily an equine disease. The bacterium has a strong affinity for horses, with donkeys and mules also susceptible, making horses the species most affected and commonly considered the primary reservoir. While other animals and even humans can become infected through exposure, the disease is most characteristic and impactful in horses. Among the listed animals, horses best fit as the primary host, which is why that option is correct.