All of the following are true regarding the treatment of Burkholderia mallei (glanders) infections regardless of clinical severity EXCEPT:

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The main idea here is that glanders caused by Burkholderia mallei requires aggressive and prolonged antibiotic therapy, with treatment decisions guided by the specific susceptibility of the organism. Starting antibiotics early with intravenous therapy helps achieve reliable and rapid tissue levels, which is important because the infection can involve multiple organs and form chronic foci. Because B. mallei can have variable resistance patterns, therapy should be guided by susceptibility testing to choose an effective combination and avoid ineffective drugs. Additionally, the infection often needs extended courses of treatment—often weeks to months—to ensure eradication and prevent relapse. Limiting oral maintenance therapy to no more than 30 days after IV therapy would generally be insufficient, making that statement the exception. The other points—early IV therapy, susceptibility-guided regimens, and the possibility of long treatment durations—fit standard management.